This highlight describes a series of novel 6-aryl isoindolin-1-one derivatives as negative allosteric modulators (NAMs) of the metabotropic glutamate receptor 2 (mGluR 2). The chemical synthesis, ...

In the intricate chemical symphony of the brain, glutamate stands as the principal conductor. As the brain's most abundant excitatory neurotransmitter, glutamate facilitates our ability to learn ...

and it will also work on a metabotropic glutamate receptor subtype 7 negative allosteric modulator (NAM). Both are in preclinical development. Other companies working on PAMs include Cerevel ...

The activation of AMPARs by glutamate is an extremely rapid process, so previous studies have used drugs to slow it down. These are typically positive allosteric modulators (PAMs), which block a ...

Department of Radiology and Imaging Sciences, Emory University, 1364 Clifton Road, Atlanta, Georgia 30322, United State ...

Its lead drug candidate, Evenamide, is a first-in-class glutamate modulator aimed at treating treatment-resistant schizophrenia and patients inadequately responding to current therapies.

In this paper, we extend a detailed glutamatergic synaptic model, to include astrocytic glutamate transporters. We demonstrate how these glial transporters, responsible for the majority of glutamate ...

Aditum funded Tempero, while Soshei licensed a suite of metabotropic glutamate receptor 5 (mGlu5) NAM modulator molecules, including TMP-301. These molecules modulate glutamate signaling in the brain, ...