Aerobic glycolysis is upregulated through the inhibition of PDH by PDK, thereby blocking Acetyl Co-A synthesis, and through the upregulation of LDHA, which produces lactate. PFK-2 and PK-M2 are ...

Lactate affects glucose metabolism by inhibiting cellular glycolysis and maintaining mitochondrial homeostasis through the inhibition of glycolytic enzymes (HK-1, PKM) and the promotion of TCA cycle ...

Respiration: Exchange gases; Cellular respiration-glycolysis, fermentation (anaerobic), TCA cycle and electron transport system (aerobic); Energy relations- Number of ATP molecules generated ...

PPA2 expression levels are reduced in CRC specimen and correlate with enhanced response to hypoxia by promoting hypoxia-inducible factor-1 (HIF-1) signaling to promote CRC cell glycolysis and ...

Objective Dysregulated cellular metabolism is a distinct hallmark of human colorectal cancer (CRC). However, metabolic programme rewiring during tumour progression has yet to be fully understood.

This manuscript offers an exploration of the immune cells in the oyster Crassostrea gigas, by correlating distinct hemocyte morphotypes with specific single-cell transcriptional profiles. The evidence ...

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