A team of researchers at Karolinska Institutet has developed a novel tool for genetic research. The study, published in ...

Human extracellular matrices can be edited in their composition using the CRISPR/Cas9 system, leading to materials exhibiting tailored regenerative capacities.

This study achieved CRISPR/Cas9-mediated genome editing in grass carp (Ctenopharyngodon idella), China's most economically vital freshwater fish. Targeting the tyrb gene critical for pigmentation were ...

A minimum of 3 positive founders will be delivered. To produce CRISPR/cas9-mediated gene indels to generate knock-out mice or rats. The investigator will provide or purchase the CRISPR gRNA(s). TGEF ...

This study shows that RNA decay rather than the presence of premature termination codons triggers a TA-like response.

However, both the Cas9 and Cas12 nucleases show some tolerance for guide RNA (gRNA) and target site mismatches, which may ...

Advances in the gene-editing technology known as CRISPR-Cas9 over the past 15 years have yielded important new insights into the roles that specific genes play in many diseases. But to date this ...

Genome editing by CRISPR/Cas9 system is a popular laboratory technique used in ... of the constructs with fluorescence microscopy and assess the functionality of the gRNA with a T7 nuclease mutation ...

CRISPR/Cas9 editing has its limitations and success of projects at ... Editing conditions are very often unique to each cell line and gene target. Do I absolutely need gRNA validations before starting ...