We demonstrate that Vif induces a highly unique and robust pseudo-metaphase arrest, irrespective of the cell line tested or its p53 status. Additionally, we found that Vpr unexpectedly induces a ...

他们通过 siRNA 敲低 HCT116 细胞中 RPS19 的表达，模拟 DBA 中 RPS19 单倍体不足的情况。结果发现，RPS19 敲低导致 40S 核糖体亚基减少，同时引发了一系列细胞反应。基因集富集分析（GSEA）显示，RPS19 或 bystin（参与 40S 成熟的核糖体生物发生因子）的缺陷会触发 p53 ...

Medicinal Chemistry, Monash Institute of Pharmaceutical Science, Monash University, 381 Royal Parade, Parkville, Victoria 3052, Australia Drug Delivery, Disposition & Dynamics, Monash Institute of ...