We found that the three DNA-damaging drugs, namely Nutlin, Doxorubicin, and 5-Fluorouracil (5-FU), stabilized p53 and concurrently repressed BLM and RAD51 in both HCT116 WT and HCT116 p21−/− cells but ...

Methods: In this study, we employed in situ ChIA-PET to investigate the colorectal cancer cell line HCT116 with p53 knockout, comparing them to cells infected with the adenovirus-vector expressing p53 ...

为探究 TRIM26 与 p53 在结直肠癌（CRC）中的关系，[第一作者单位名称] 研究人员开展相关研究。结果发现 TRIM26 可促进 CRC 细胞增殖和肿瘤生长，或可作潜在治疗靶点。推荐一读，助您了解癌症研究新进展。 在癌症研究的神秘领域中，有一个 “神秘嘉宾 ...

To demonstrate the utility of TF-chRDP, we applied this method to investigate protein-DNA-RNA complexes bounded to the transcription factor p53 in human colon cancer cells (HCT116). Under normal ...

这两个过程紧密相连，比如肿瘤抑制蛋白 p53，它既能诱导细胞凋亡 ... 研究人员用 MDM2 抑制剂 AMG 232、CDK7 抑制剂 YKL-5-124 和 PLK1 抑制剂 volasertib 这三种化合物处理 HCT116 细胞（一种人结肠癌细胞系），通过细胞计数和 WST 检测评估细胞群体生长情况。

We demonstrate that Vif induces a highly unique and robust pseudo-metaphase arrest, irrespective of the cell line tested or its p53 status. Additionally, we found that Vpr unexpectedly induces a ...

Figure 8: Regulation of ALDH3A1 and NECTIN4 by p53. Researchers Jessica J. Miciak, Lucy Petrova, Rhythm Sajwan, Aditya Pandya, Mikayla Deckard, Andrew J. Munoz, and Fred Bunz from the Sidney ...

MANILA – The Philippine Economic Zone Authority (Peza) has approved P52.93 billion worth of investment pledges in the first two months of the year. PEZA reported Tuesday that its investment ...

The intrinsic factor of cell senescence, PCBP2, was identified by unlabeled quantitative proteomics, and its biological role in in vitro replication senescence of human bone marrow mesenchymal stromal ...

Creative Commons (CC): This is a Creative Commons license. Attribution (BY): Credit must be given to the creator.