University of Illinois at Chicago, Chicago, IL.

在 U87MG 细胞中，过表达 PHGDH 能调节多个基因的表达，且该调节作用依赖于其核定位，而非酶活性。 PHGDH 调节 IKKα 和 HMGB1 表达：通过整合多种数据分析，确定 IKKα 和 HMGB1 为 PHGDH 的潜在转录靶基因。在 U87MG 细胞和 BOs 中，PHGDH 能激活 IKKα 和 HMGB1 的启动子 ...

The authors do not work for, consult, own shares in or receive funding from any company or organization that would benefit from this article, and have disclosed no relevant affiliations beyond ...

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