第十版教材——子宫颈上皮内病变（cervical squamous intraepithelial lesion）是与子宫颈浸润癌密切相关的一组子宫颈病变，包括经组织学确认的子宫颈鳞状上皮内病变和腺上皮内病变，是子宫颈癌的前驱病变。

这篇研究聚焦人乳头瘤病毒（HPV）相关宫颈癌。发现视网膜母细胞瘤蛋白（pRB）不仅是 HPV E7 的降解靶点，还对 E7 蛋白稳定至关重要。pRB 缺失会降低 E7 水平，抑制癌细胞增殖，为 HPV 相关癌症研究提供新思路。

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