however the majority of oncogenic HPV infections were also cleared within 24 months. The incidence of cervical intraepithelial neoplasia (CIN) is tenfold higher than the incidence of dysplasia in ...

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As a result, these patients should be referred for colposcopy (Figure 3). Repeat cytology and HPV testing are indicated for risk assessment only if colposcopic findings are negative for CIN.

Here, the authors characterize the epigenetic status of hybrid ecDNA in HPVOPC, identifying HPV oncogenes E6/E7 in hybrid ecDNA are flanked by somatic DNA enhancers with strong cis-interaction.