这篇研究聚焦人乳头瘤病毒（HPV）相关宫颈癌。发现视网膜母细胞瘤蛋白（pRB）不仅是 HPV E7 的降解靶点，还对 E7 蛋白稳定至关重要。pRB 缺失会降低 E7 水平，抑制癌细胞增殖，为 HPV 相关癌症研究提供新思路。

虽然我们早已知道 HR-HPV 的 E6 和 E7 这两种癌蛋白在致癌过程中 “兴风作浪”，可它们具体是如何 “作恶” 的，还有哪些潜在的 “帮凶”，一直是科学界亟待解开的谜题。而且，目前针对 HPV + 癌的治疗手段有限，急需开辟新的治疗路径。 在这样的背景下 ...

In this article we give an overview of RNA-based HPV diagnostics and the role of E6/E7 mRNA detection as a predictive marker for the development of cervical carcinoma. HPV E6/E7 mRNA testing for ...

Gen-Probe is currently developing the APTIMA HPV Assay, targeting E6/E7 mRNA from 14 carcinogenic HPV genotypes. A prototype of this assay was evaluated recently in 536 women with histological ...

The researchers can model this either by editing the genes themselves or inhibiting their expression with HPV E6 and E7 oncoproteins. These two oncoproteins help drive HPV-associated cancers by ...

Enzo’s innovations are changing the story of HPV. The FLOWSCRIPT® Assay employs a novel, flow cytometry-based, in situ hybridization technique, utilizing a cocktail of probes specific to multiple ...

The E6 and E7 proteins are key oncogenes in the development of HPV-associated tumors, and therapeutic vaccines targeting HPV16 E6 and E7 tumor-specific antigens -- such as Vvax001 -- "represent an ...

"Nearly all premalignant cervical lesions and cervical cancers are caused by HPV infection ... cannot replicate and produces the oncogenic E6 and E7 proteins that are expressed exclusively ...