HSP60 单体包含赤道面、中间和顶端三个结构域，能与 HSP10 形成稳定的七聚体单环或双环结构，辅助蛋白质折叠。HSP70 由 N 端的核苷酸结合结构域（NBD）和 C 端的底物结合结构域（SBD）组成，通过二者之间的灵活连接实现变构调节。HSP90 由 N 端结构域（NTD）、中间 ...

Targets for degradation are redirected to the proteasome through interaction with co-chaperones, including the C-terminus of HSC70-interacting protein (CHIP) and Bcl2-associated athanogene 1 (BAG1), ...

The emergence of immunotherapies has revolutionized cancer treatment by leveraging the immune system to target malignancies, offering new hope where traditional therapies often fall short. Within this ...