Shanghai Engineering Research Center of Molecular Therapeutics and New Drug Development, School of Chemistry and Molecular Engineering, East China Normal University, 3663 North Zhongshan Road, ...

Necroptosis is a form of regulated necrosis that requires the activation of receptor-interacting kinase 3 (RIPK3 or RIP3) and its phosphorylation of the substrate MLKL (mixed lineage kinase ...

PARP7 is a mono-ADP-ribosyl transferase (mono-ART) which has recently gained attention due to its emerging role as a negative ...

Biodiscovery Institute, School of Pharmacy, University of Nottingham, University Park, Nottingham NG7 2RD, U.K.

The development of pharmaceuticals is crucial due to the potential risk of Torsades de Pointes (TdP). For that reason, in the 1990s–2000s, several drugs were withdrawn from the market due to their ...

A novel, allosteric and highly potent USP1 inhibitor, LAE120 exhibits robust tumor inhibitory activity across various xenograft models Significantly accelerated the progress of drug discovery ...