当药物在体外抑制 hERG 离子通道时，会引发体内 QT 间期延长，这就像一颗 “定时炸弹”，大大增加了如尖端扭转型室性心动过速（Torsade de Pointes，TdP）等严重心律失常的风险。由于这个风险，许多原本很有潜力的药物，仅仅因为在早期发现有 hERG 活性，就不得 ...

Pharmacogenomics. 2012;13(2):223-231.

Ewa Moric-Janiszewska, Ph.D.; Grazyna Markiewicz-Loskot M.D. Ph.D.; Maria Loskot M.D.; Ludmila Weglarz; Andrzej Hollek M.Sc.; Leslaw Szydlowski M.D.

Background: The specific and non-specific toxicities of cryoprotective agents (CPAs) for semen or spermatozoa cryopreservation/vitrification (SC/SV) remain challenges ...

In this important study, the authors test the model that a type of vascular lesion caused by the inactivation of one gene in the cells that line blood vessels requires the activity of a second gene ...

Department of Medicine, University of California, San Diego, United States; ...

Shanghai Engineering Research Center of Molecular Therapeutics and New Drug Development, School of Chemistry and Molecular Engineering, East China Normal University, 3663 North Zhongshan Road, ...