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探秘海洋链霉菌:挖掘非典型环肽合成酶,解锁新型抗炎活性分子
为探究海洋链霉菌非典型非核糖体肽合成酶(NRPS)的奥秘,研究人员挖掘其生物合成基因簇(BGC)并异源表达。结果发现新环肽 jejumide,结构似真菌来源,且具抗炎活性。这为新型生物活性化合物研发提供方向。 在神秘的海洋世界里,链霉菌(Streptomyces)宛如 ...
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