Mouse study identifies shared genes involved in hearing and vision regeneration
The same genes could hold the key to regenerating cells in the ear and eye, according to a new mouse study from the USC Stem ...
Gene Switch Reboots Sight and Sound: A Breakthrough in Sensory Regeneration
A USC research team discovered that a single genetic signal may be preventing both hearing and vision cells from repairing ...
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Review highlights the interplay of TGF-β and HIPPO pathways in liver regeneration and disease
Among these signals, the TGF-β and HIPPO pathways are critical, functioning as tumor suppressors and regulating liver development and regeneration. The review focuses on these pathways' interplay ...
BioWorld12d
Study finds Hippo pathway aberrantly activated in NPH1 models, unveiling Kibra as a potential target
Nephronophthisis (NPH) is a recessive cystic kidney disease responsible for 10% to 20% of pediatric end-stage renal disease cases. NPHP1 (nephrocystin 1) is the most frequently implicated among over ...
Mena FN19d
Vivace Therapeutics Raises $35 Million In Series D Financing To Support Clinical Development Of First-In-Class Cancer Drug Targeting The Hippo Pathway
SAN MATEO, Calif., March 12, 2025 /PRNewswire/ -- Vivace Therapeutics, Inc., a small molecule discovery and development company developing first-in-class cancer therapies targeting the Hippo pathway, ...
The Scientist2y
The heart's limitations
Two seemingly disparate signaling pathways -- one that controls organ size in fruit ... to restrict cell proliferation and control heart size. Wild-type (left) and Hippo mutant (right) neonate mouse ...
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Vivace closes $35m in Series D for cancer drug development
VT3989 is a transcriptional enhanced associate domain (TEAD) autopalmitoylation inhibitor that blocks the palmitoylation of TEAD protein family members to target the Hippo pathway. RA Capital ...
Baylor College of Medicine4y
James Martin Lab
The lab reported in the journal Science that a gene pathway called Hippo inhibits cardiac muscle regeneration during development. View the Science Journal article. Our lab is currently working to ...