Our hypothesis rests on the central concept that mammalian histone H3 variants (H3.1, H3.2, and H3.3), although remarkably similar in amino acid sequence, exhibit distinct posttranslational ...

Bengaluru scientists have developed a salt-resistant rice variant, offering hope against rising soil salinity. The breakthrough could enhance global food security.

Cancer mutations in histone H3 cause genome instability, but the mechanisms remain to be elucidated. Here, the authors show in a plant model that the oncohistone H3.1K27M disrupts the TSK/TONSL-H3 ...

University Grenoble Alpes, CEA, INSERM, UA13 BGE, CNRS, CEA, 38000 Grenoble, France ...

Previously, we reconstituted a minimal functional kinetochore from recombinant S. cerevisiae proteins that was capable of transmitting force from dynamic microtubules to nucleosomes containing the ...

"Manipulating the H3.3 pathway may provide a way to completely wipe a cell's ‘memory’ and produce a truly pluripotent cell,” geneticist Steven Henikoff, from the Fred Hutchinson Cancer Research Center ...

A landmark review in Nature Reviews Genetics dissects the rare and common genetic variants that shape human height. The paper explains how monogenic and polygenic factors converge on key growth ...

Johns Hopkins University, Baltimore, MD.

The findings could serve as the basis for detecting disease-associated variants in a range of common diseases. Researchers from Children's Hospital of Philadelphia (CHOP) and the Perelman School ...

In Season 1, we met one of the variants, "clickers," who hunt by sound and are extremely dangerous. Clickers aren't the only variant hiding out in the wastes of the world. In the first episodes of ...

This study provides valuable findings on the role of site-specific DNA methylation changes during spermatogenesis and their contribution to paternal epigenetic inheritance. The study proposes that ...