When methylation affects CpG islands ... allowing heterochromatin protein 1 (HP1) to bind; eventually resulting in closed chromatin (bottom right). After DNA replication, newly synthesized ...

Histone deacetylases (HDAC) remove acetyl groups from lysine residues making way for methylation. HP1 recognizes MeK9 and also associates with histone methyltransferases (HMT), DNA methyltransferases ...

Cytosine methylation of CpG dinucleotide clusters ... attracts chromodomain binding proteins (heterochromatin protein, HP1) that maintain the heterochromatin state. What lends to further ...