Around 80% of human proteins have traditionally been deemed ‘undruggable’ because they lack suitable binding pockets that conventional drugs need to be effective. Known as targeted protein ...

To develop a small-molecule drug, researchers spend years combing ... 250,000 of which were previously unknown, including every human protein and many made by mice, fruit flies, E.

Researchers used integrated Mendelian randomization in a cohort of over 247,000 individuals to identify 62 plasma proteins associated with breast cancer risk. Nine high-confidence targets, including ...

ATTR-CM is a disease in which harmful proteins build up in ... The U.S. Food and Drug Administration is replacing animal testing with human-relevant methods, including artificial intelligence ...

Drug-resistant bacteria are one of the most urgent threats in modern medicine. But scientists are looking to oysters for help ...

A University of Iowa-led study has revealed the unexpected structure adopted by the DNA repair protein RAD52 as it binds and protects replicating DNA in dividing cells. This new structural and ...

There are a wide variety of protein-based drugs that are used to treat various serious conditions. Insulin is perhaps the most well-known example, which is used for life-saving treatments for ...

First discovered more than 20 years ago, PINK1 is a protein directly ... s disease affect human PINK1.” The idea of using PINK1 as a target for potential drug therapies has long been ...

Researchers found a protein that's essential for an enterovirus to enter human cells. Although not the infamous example—that ...

Traditional approaches to drug discovery have relied on testing ... "As many as 85% of all human proteins are thought to be 'undruggable,'" says Alex Zhavoronkov, one of the study's co-authors ...