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探秘骨髓脂肪组织:昼夜节律、芳烃受体与白血病的神秘关联
白血病细胞可改变骨髓微环境来维持生存,其中骨髓脂肪组织(BMAT)的脂解作用对白血病发展意义重大,但相关机制不明。研究人员对健康供体、急性髓系白血病(AML)及范可尼贫血(FA)患者的 BMAT 进行多组学分析,揭示了相关分子机制,为白血病治疗提供新方向。
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