Moreover, we recently found that ET-1 induced apoptosis resistance in normal lung fibroblasts through the upregulation of survivin, a member of the Inhibitor of Apoptosis (IAP) protein family. In the ...

Host cells activate cell death pathways in response to bacterial manipulation of innate immune signalling, but the molecular ...

The data to be presented encompasses five of the company’s novel drug candidates: BCR-ABL tyrosine kinase inhibitor olverembatinib (HQP1351), Bcl-2 inhibitor lisaftoclax (APG-2575), FAK/ALK/ROS1 ...

推荐语：这篇综述系统阐述了X连锁凋亡抑制蛋白（XIAP）通过抑制caspases、激活核因子κB（NF-κB）等通路调控凋亡的双重途径（死亡受体与线粒体途径），其异常表达与肿瘤发生发展密切相关，为靶向治疗提供了新思路。 XIAP的结构与功能特性 X连锁凋亡抑制蛋白 ...

Many of the cells in our bodies are quiescent, that is, temporarily not dividing. Under certain physiological conditions such as during tissue repair and maintenance, quiescent cells receive the ...

Excessive cell death has been associated with chronic inflammation as seen in patients with Crohn's disease and ulcerative colitis. While until recently apoptosis was discussed as being essential for ...

美国马里兰州罗克维尔市和中国苏州2025年3月26日 /美通社/ -- 致力于在血液肿瘤等领域开发创新药物的领先的生物医药企业——亚盛医药（纳斯达克代码：AAPG；香港联交所代码：6855）今日宣布，公司共有五项临床前研究进展入选2025年美国癌症研究协会（AACR）年会。此次会议将于 2025 年 4 月 25 日至 30 日在美国芝加哥举行。

Department of Chemistry and Biochemistry, University of California, Los Angeles, Los Angeles, California 90095, United States Neuroscience Interdepartmental Program, University of California, Los ...