GTPase activity of ARF1 is dispensable for mitochondrial maintenance. STING inhibitor H-151 and amlexanox reduce chronic IFN signalling in patient fibroblasts. In this study, we present data relating ...

The ARF1 R19C variant selectively impairs STING retrograde transport without affecting mitochondrial integrity. GTPase activity of ARF1 is dispensable for mitochondrial maintenance. In this study, we ...

为探究 TBK1 如何转运至 TGN 激活 STING-IFN-I 信号通路，研究人员发现 TGN 拴系因子不可或缺，这对理解衰老相关免疫变化意义重大。 在人体的免疫系统中，存在着一套精密的防御机制，其中 cGAS-STING 通路（环鸟苷酸 - 腺苷酸合成酶 - 干扰素基因刺激蛋白通路 ...

Activated STING translocates to the Golgi apparatus, where it activates TBK1, leading to the phosphorylation of both STING and IRF3. Phosphorylated IRF3 dimerizes and induces the transcription of ...

hospk.ncgm.go.jp Objective The clinical significance of polymorphisms in the interleukin-28B gene encoding interferon (IFN)-λ3, which has antiviral effects, is known in chronic HCV but not in HBV ...

▎药明康德内容团队编辑（来源：复旦大学）近日，复旦大学附属华山医院刘杰教授、骆菲菲研究员团队在《肿瘤细胞》（Cancer Cell）发表题为“Targeting tumor monocyte-intrinsic PD-L1 by rewiring ...

I 型干扰素 （IFN-I） 信号在系统性红斑狼疮 （SLE） 发病过程里的作用已得到充分证实。而目前发现的单基因系统性红斑狼疮样疾病（monogenic systemic lupus erythematosus ）的主流是自身炎症I ...

Sting and Trudie Styler have some incredibly exciting news in the family from their eldest child Mickey Sumner. Taking to Instagram on Thursday, the actress, who starred alongside Emma Stone and ...