Like most plasma membrane proteins, type I interferon (IFN) receptor (IFNAR) traffics from the outer surface to the inner compartments of the cell. Long considered as a passive means to simply control ...

Can the authors compare the activation of IFN-λ signaling pathway in Plscr1-KO cells expressing empty vector, WT Plscr1, and 5CA mutant? This could be done by measuring downstream ISG expression or ...

Objectives To investigate downstream molecules of the IFN signalling pathway on B cells and their clinical impact in pSS ... levels leading to a personalized approach for this specific subgroup of ...

PARP7 is a mono-ADP-ribosyl transferase (mono-ART) which has recently gained attention due to its emerging role as a negative ...

Our findings revealed that SC significantly inhibited tumor growth in models of both breast and colon cancer. This suppression of tumor growth was attributed to the activation of type I IFN response ...

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Host cells activate cell death pathways in response to bacterial manipulation of innate immune signalling, but the molecular ...

State Key Laboratory of Oncology in South China, Guangdong Provincial Clinical Research Center for Cancer, Sun Yat-sen University Cancer Center, China; Center for Translational Medicine, The First ...