Lirum Therapeutics, Inc. (“Lirum”), an innovative clinical-stage biopharmaceutical company focused on the treatment of debilitating diseases, announced today the presentation of ...

Upon binding, IGF-1R undergoes autophosphorylation, initiating a cascade of intracellular signaling pathways, including the phosphoinositide 3-kinase (PI3K)/Akt and the Ras/mitogen-activated protein ...

The type 1 IGF receptor (IGF-IR) is activated by two ligands, IGF-1 and IGF-2, and by insulin at supraphysiological concentrations. It plays a significant role in the growth of normal and abnormal ...

is an inducible negative regulator of the JAK/STAT pathway, implicated in various inflammatory diseases. In this study, we investigated the role of SOCS3 in the inflammatory and adipogenic ...

DelveInsight’s “TEPEZZA Market Size, Forecast, and Market Insight Report” highlights the details around TEPEZZA, an insulin-like Growth Factor-1 receptor (IGF-1R) inhibitor. The report ...

Peptide mimics must also be designed to adopt structures of the corresponding ligand or receptor to function as effective inhibitors of signaling pathways. Combining minimal doses of ...

Other reports have also indicated that the IGF-1 signaling pathway may be implicated in several cancers (41 ... Paraffin-embedded sections were deparaffinized, stained with an antibody against IGF-1 ...

Insulin-like growth factor (IGF) 1 is a member of a family that is ... Upon binding to the GH receptor, this hormone activates signaling pathways that lead to transcriptional activation or ...