Specifically, based on its mechanism, “IL-23 is viewed by some as the overarching master cytokine in the psoriasis pathway,” said Fernandez, clinical assistant professor in the Department of ...

By uncovering that it is selectively upregulated on ILC3s by IL-23, this demonstrates that we should be thinking about these pathways more broadly to develop more selective therapeutics." ...

ORLANDO -- Two-thirds of patients with moderate or severe plaque psoriasis had complete or nearly complete clearance at 4 ...

The IL-23/IL-23R signalling pathway plays a vital role in the pathogenesis of plaque psoriasis and other immune-mediated inflammatory diseases. JNJ-2113 selectively inhibits IL-23 signalling and ...