Antineutrophil cytoplasmic antibody (ANCA)-associated vasculitis (AAV) characterized by a dominant antimyeloperoxidase (MPO) response mediated by CD27+IgM+ B cells exhibited persistent memory-like ...

In response to T-cell-dependent antigens, mature B cells in the secondary lymphoid organs are stimulated to form germinal centers (GCs), which are histological structures deputed to antibody affinity ...

The deal with startup Dren Bio hands Sanofi a so-called myeloid cell engager that would compete with an array of programs ...

They recombinantly expressed an IgM that binds to ganglioside GM3 and kills GM3 positive human myeloma cells in the presence of complement. The hexameric form without J-chain and the pentameric form ...

When your doctor talks to you about your B-cell lymphoma ... If you have this cancer, you make too much of a protein called immunoglobulin M (IgM). You may get symptoms such as bleeding easily ...

IgM 0.4–2.3 g/L, IgA 0.7–4 g/L). ANCA staining patterns were assessed by indirect immunofluorescence. The specificity of ANCA for myeloperoxidase or proteinase was assessed by ELISA (Euroimmun) or by ...

Orphan Drug Designation follows positive Phase 1 data presented at the 12th International Workshop on Waldenström ...

Upregulated STAT1 and IRF9 within pSS B cells were associated to extraglandular manifestations, high anti-SS-A and anti-SS-B autoantibodies, high anti-nuclear antibody titers (ANA) and rheumatoid ...

Bexobrutideg, a bioavailable agent, was granted orphan drug designation by the FDA for Waldenström macroglobulinemia, a type ...

28 As they are involved in the neutralisation of circulating endotoxin, EndoCAb immunoglobulins are typically depleted in response to an acute LPS exposure, but eventually rise due to the B-cell ...