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构建针对铜绿假单胞菌耐药机制的抗生素评估系统
在本研究中,缺失OprD孔蛋白会导致亚胺培南(imipenem)和美罗培南(meropenem)的最小抑菌浓度(MIC)增加≥4倍,而其他外膜孔蛋白的缺失对所有测试抗生素的MIC影响较小(2倍)。这一结果与之前的研究一致,表明在40种可识别的孔蛋白中,只有碳青霉烯类抗生素 ...
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