In a study published in Angewandte Chemie International Edition, a research team integrated activity-based protein profiling ...

Laboratory models demonstrated that inhibiting APOC1 not only halted the proliferation of tumor cells but also reduced the formation of new blood vessels. This effect was associated with decreased ...

Discover the symptoms, causes and treatments for hereditary angioedema, a rare genetic disorder causing severe swelling that ...

Researchers at Cold Spring Harbor Laboratory have found that blocking the FGFR2 and EGFR genes can stop early-stage ...

Using the power of AI and the world-class Aurora supercomputer, scientists at Argonne are breaking new ground in cancer research, screening billions of molecules in minutes and aiming to inhibit ...

Isosterix Inc. has synthesized histone acetyltransferase KAT6A (monocytic leukemia zinc finger protein; MOZ; MYST-3) inhibitors reported to be useful for the treatment of cancer.

At Argonne National Laboratory near Chicago researchers are using AI and high performance computing to develop new methods ...

Tocilizumab has emerged as a key treatment for rheumatoid arthritis, showing efficacy, safety, and potential cardiovascular ...

The MECP2 protein has DNA- binding activity which is required for oncogenic transformation and binding is dependent on cytosine methylation. Therefore, MECP2 DNA binding may be targeted by inhibiting ...

Background Fibrolamellar carcinoma (FLC), a rare and fatal liver cancer lacking effective drug therapy, is driven by the DNAJ-PKAc fusion oncoprotein. However, the underlying mechanism of DNAJ-PKAc’s ...

The Medicines and Healthcare products Regulatory Agency (MHRA) has approved the medicine marstacimab (Hympavzi) to prevent or reduce bleeding in patients 12 years of age and older weighing at least 35 ...