In a study published in Angewandte Chemie International Edition, a research team integrated activity-based protein profiling ...

Inhibitors of Apoptosis Proteins (IAPs) are a family of anti-apoptotic proteins that play a pivotal role in apoptosis in general but also as oncoproteins in cancer progression and, more importantly, ...

Laboratory models demonstrated that inhibiting APOC1 not only halted the proliferation of tumor cells but also reduced the formation of new blood vessels. This effect was associated with decreased ...

Discover the symptoms, causes and treatments for hereditary angioedema, a rare genetic disorder causing severe swelling that ...

Researchers at Cold Spring Harbor Laboratory have found that blocking the FGFR2 and EGFR genes can stop early-stage ...

Using the power of AI and the world-class Aurora supercomputer, scientists at Argonne are breaking new ground in cancer research, screening billions of molecules in minutes and aiming to inhibit ...

At Argonne National Laboratory near Chicago researchers are using AI and high performance computing to develop new methods ...

This was shown using the ER-resident PDI-like protein AGR2 that is refluxed from the ER of cancer cells to interact and inhibit the activity of prosurvival proteins in the cytosol, especially wt-p53.

Tocilizumab has emerged as a key treatment for rheumatoid arthritis, showing efficacy, safety, and potential cardiovascular ...

The MECP2 protein has DNA- binding activity which is required for oncogenic transformation and binding is dependent on cytosine methylation. Therefore, MECP2 DNA binding may be targeted by inhibiting ...

Background Fibrolamellar carcinoma (FLC), a rare and fatal liver cancer lacking effective drug therapy, is driven by the DNAJ-PKAc fusion oncoprotein. However, the underlying mechanism of DNAJ-PKAc’s ...