Dolutegravir is an HIV integrase strand transfer inhibitor (INSTI ... enzymes and therefore is associated with few drug interactions other than metformin and dofetilide. Dolutegravir should ...

cART suppresses the proliferation of drug-resistant mutant strains by ... a PI boosted with RTV (another PI), an integrase inhibitor or an entry inhibitor. Many initial ART regimens based on ...

The HIV treatment landscape has further evolved with the introduction of LAI therapies, offering alternatives to daily oral ...

Angiotensin-converting enzyme (ACE) inhibitors are oral medications that lower blood pressure. They are used to treat a variety of heart-related conditions including high blood pressure, coronary ...

The Food and Drug Administration (FDA ... NS-229 is an investigational selective Janus kinase 1 (JAK1) inhibitor designed to prevent tissue damage caused by EGPA by suppressing immune cell ...

In their paper, the team concluded that revealing the binding poses of three major inhibitor classes will allow “… further exploration of MPC as a drug target for treating diabetes mellitus ...

Dovato is the top-selling drug in GSK's HIV portfolio ... GSK also reported preliminary results with a third-generation integrase inhibitor, VH4524184, which is effective against HIV, but seems ...

Tumors with homologous recombination defects (HRD) due to mutations in BRCA1/2 genes or other genes associated with HR repair are typically sensitive to poly(ADP-ribose) Polymerase 1/2 inhibitors ...

Most new cancer diagnoses occur in people 65 and older, and overall these folks have worse cancer treatment outcomes, researchers said in background notes. Adobe stock/HealthDay It's well-known ...