A substantial and persuasive body of data now exists that supports the view that integrin alpha V beta 3 plays a critical part in activated macrophage dependent inflammation, osteoclast development, ...

Consistent with this possibility, we found that the rate of spontaneous dissociation of RhoGDI1 from prenylated Cdc42, which we independently measured by a FRET-based chase assay in the absence of ...

为解决 Ephexin5（E5）在神经元可塑性调节中作用机制不明的问题，研究人员开展了 E5 对 Cdc42 和 RhoA 调控作用及相关机制的研究。结果表明 E5 可激活 Cdc42 和 RhoA，且其底物选择性受神经元活动和酪氨酸磷酸化调控，该研究为相关疾病治疗提供新思路。 大脑中的 ...

The Key Laboratory of Biomedical Information Engineering of Ministry of Education, School of Life Science and Technology, Xi’an Jiaotong University, Xi’an 710049, P.R. China Bioinspired Engineering ...

Rho家族GTP酶在PEDV诱导的信号通路中的作用 研究揭示了Rho家族GTP酶在PEDV诱导的Cofilin活性调节中的重要作用。Western blot分析显示，在感染初期，Cdc42和Rac1的活性被短暂诱导，而RhoA的活性未发生显著变化。进一步实验表明，Rac1和Cdc42的抑制剂能够阻断PEDV诱导的Cofilin ...

This cover highlights the article PLK1 inhibition delays mitotic entry revealing changes to the phosphoproteome of mammalian cells early in division by M. Gobran, P. Lenart and colleagues. HeLa Kyoto ...

Introduction: Among the various stromal cell types within the tumor microenvironment, cancer-associated fibroblasts (CAFs) emerge as the predominant constituent, exhibiting a diverse array of ...

Department of Rheumatology, Translational Research Group, Dublin Academic Medical Centre, St Vincent's University Hospital, Dublin, Ireland Correspondence to Dr Ursula Fearon, Department of ...