Microglia, the brain's immune cells, usually serve as diligent guardians. They eliminate intruders such as microbes and clear ...

We also evaluated cytokines of the cerebrospinal fluid and brain regional volumes in patients with dNPSLE and patients with non-dNPSLE. Conclusions The microglial IL-12/23 axis in the mPFC might be ...

KaliVir Immunotherapeutics, Inc., a clinical-stage biotechnology company developing cutting-edge, multi-mechanistic oncolytic immunotherapy programs, today announced the upcoming presentation of a ...

During this mission, the team will grow Janus base nanotubes that carry interleukin-12. Interleukin-12 is a protein already produced naturally by the human body, but only in small quantities. It ...

A new study reveals that IL-12, an inflammatory molecule, accelerates Alzheimer’s disease by damaging brain cells and ...

Biologics targeting interleukin-12, -23, and -17 were associated with a lower rate of serious infections among older adults ...

Researchers have detailed the precise mechanism through which the inflammatory signaling molecule IL-12 contributes to Alzheimer's disease.

When interleukin-12 is added to the cell culture, it leads to a significant reduction in nerve fibers (pink) and oligodendrocytes, and thus to a decline in myelin (white).

IL-23, or IL-17 reduced serious infections, while tofacitinib increased infection risk, according to one study.

While some continue to function effectively, others gradually lose their protective role and start secreting small amounts of inflammatory messengers. One such messenger is interleukin-12 (IL-12).