为探究胎儿尿道下裂病因，研究人员对孕期超声发现胎儿尿道下裂的病例进行研究。经羊水穿刺、 trio 全外显子测序，发现胎儿KAT6B基因新的移码突变（KAT6B: exon10: c.2153_2159del, p. R718Lfs3），且为de novo突变。该发现拓宽了KAT6B变异谱及疾病基因型 - 表型关系。

多种癌症中存在 KAT 基因的基因组和转录组改变，如 Moz 和 Morf 在多种癌症中反复扩增，KAT2A、KAT2B、KAT6A、KAT6B 等也与癌症的发生、发展相关 。KAT 可促进细胞身份危机，通过打开染色质激活新的基因表达网络，还可作为转录因子（如 MYC）的共激活剂，改变染色质 ...

But there was more to the final over than just those last two deliveries. Heart-racing, nerve-wracking, and simply unforgettable! #LSG defy the odds and seal a 2-run victory over #RR after the ...

Getting attention — Sen. Van Hollen met with Abrego Garcia: Sen. Chris Van Hollen (D-Md.) traveled to El Salvador and met with Kilmar Abrego Garcia, who was wrongly deported to the Terrorist ...

This scientifically-backed supplement is designed to promote nerve health and alleviate discomfort through a unique blend of high-quality ingredients. With its commitment to safety and efficacy ...

Everyone has most likely gone on a bad first date, but probably not one involving blackmail and murder. Director Christopher Landon turns a deceptively simple premise into a taut, tech-fueled ...

As someone who has struggled with nerve pain for a significant part of my life, finding a reliable and effective supplement has been challenging. After trying numerous products that promised relief ...

romantic thriller with iconic characters and nerve shredding action. "Jo is a character close to our hearts. She is an ordinary woman facing extraordinary odds. We can't wait for audiences to meet ...

Add articles to your saved list and come back to them any time. By the time Xi Jinping touched down in Hanoi on Monday afternoon, as part of a five-day charm offensive in South-East Asia, the ...

Popular fast-food chain Wendy’s took aim at Katy Perry after she returned to Earth as part of an all-female Blue Origin mission. On Monday, the “E.T.” singer joined Gayle King and Jeff Bezos ...

U.S. President Donald Trump delivered jokes after jokes as he welcomed Philadelphia Eagles to the White House. Trump came up with a laughable reason to avoid standing next to Eagles owner Jeffrey ...

This time, thanks to a regional nerve block, her pain was well controlled. No opioids, no haze, just calm. That moment made me reflect on a larger question: Are we doing enough to personalize ...