and point mutations in the tyrosine kinase domain (~5%), commonly at the activation loop residue D835. Secondary kinase domain mutations in FLT3-ITD, particularly at the D835 residue are ...

The phosphoinositide 3-kinase (PI3K) pathway is a crucial signal ... Oncogenic activation of this pathway commonly occurs through activating mutations in the p110α isoform of PI3K or through ...

It was found that a phospho-dead mutation at Y163 abolished the inhibitory ... In a search for the kinase responsible for PDK1 Y163 phosphorylation, TIE1 was identified as a potential candidate.

It was found that a phospho-dead mutation at Y163 abolished the inhibitory ... In a search for the kinase responsible for PDK1 Y163 phosphorylation, TIE1 was identified as a potential candidate.