The involvement of the Ku70 protein also hints at a role of the Mlp proteins in regulating DNA repair. The obvious next step is to determine whether an association between NPC core proteins ...

为探究此问题，研究人员以结肠癌为研究对象，聚焦 mutant p53（mutp53）。研究发现 mutp53 通过上调 HDAC6，维持 Ku70 水平，减轻 ER 应激诱导的 DNA 损伤。该成果为攻克 mutp53 相关癌症提供新方向。 在癌症的复杂世界里，癌细胞就像一群顽强的 “敌人”，拥有多种 ...

PEX5 was revealed as a target gene of miR-4274, with the deletion genotype of rs1553867776 leading to downregulation of PEX5 protein ... that PEX5 interacts with Ku70 in the cytoplasm, preventing ...