Cold plunges have become a fixture on wellness feeds and gym schedules. But what does science say when you strip away the ...

【导读】自噬是一种高度保守的细胞过程，对于维持细胞内稳态以及影响癌症的发展至关重要。3月25日，南昌大学/南方科技大学研究人员合作共同在期刊《Cell Death&Disease》上发表了研究论文，题为“ATP6AP1 promotes cell ...

Autophagy is a highly conserved lysosomal degradation system that involves the creation of autophagosomes, which eventually fuse with lysosomes and breakdown misfolded proteins and damaged organelles ...

Notably, a large number of vesicles with double-membrane structure indicating autophagosome were found to surround the aberrant spermatozoa, suggesting the activation of autophagy. Several proteins, ...

Autophagy was quantified by western blotting of LC3, transmission electron microscopy analyses and confocal microscopy scanning of mRFP-GFP-LC3 reporter construct. Luciferase reporter assays were ...

牙周炎（Periodontitis）是一种常见的口腔慢性炎症性疾病，是成人牙齿脱落的原因之一。已有研究表明，牙周炎的发生与巨自噬/自噬（Macroautophagy/autophagy）过程有着复杂的联系，自噬像一把双刃剑，在维持牙周稳态中起到双重作 ...

Rapamycin effects on mTOR signalling, autophagy, cartilage homeostasis and inflammation were analysed by immunohistochemistry and immunofluorescence staining. Results Rapamycin affected the mTOR ...

In this study, we also found that overexpression of SIRT1 could inhibit the expression of autophagy marker p62 and promote the expression of LC3-II/I and Beclin1, while the addition of 3-MA partially ...

In the siRNA knockdown group, synuclein and LC3 showed normal anterograde axoplasmic transport, while retrograde axonal transport was blocked. The changes in intracellular autophagy flow, that is, the ...