This review will focus on transcriptional, posttranscriptional, and posttranslational pathways that regulate the LDLR and its availability at the plasma membrane (Figure 1). The concept that LDL was ...

LDL receptor-related protein 1B (LRP1B) may play a crucial role in tumorigenesis and ... Molecular mechanism studies revealed that LRP1B negatively regulated the Hedgehog (Hh) signaling pathway, ...

Reagents: FA (Solarbio, Cat.F8330); Dimethyl Sulfoxide (DMSO) (Solarbio, Cat.D8370); ox-LDL (Yiyuan, Cat.YB-002-1); Fetal Bovine Serum (Biosharp ... and vascular endothelial growth factor receptor-1 ...

As a result, oxidized LDL is continuously taken up via these receptors, loading the macrophages ... by inhibition of Rho signaling pathway and, through PPARα, increased apoA-I gene transcription ...

Researchers explore how natural compounds in traditional Chinese medicine can modulate cholesterol metabolism to combat cancer.

Gypenoside L can also regulate the methyl valproate (MVA) pathway by targeting SREBP2 ... pick type C1-like 1 (NPC1L1) and low-density lipoprotein receptor (LDLR). However, ezetimibe, which ...

J&J exhibited additional findings from the Vivacity-MG3 study, displaying that nipocalimab met its key secondary endpoint.

Chen says. However, the diterpene compounds seem to impact how much LDL receptors in cells are able to process circulating LDL in the body, he says. Diterpenes also seem to suppress enzymes linked ...

Tourmaline Bio's Pacibekitug shows promise in IL-6 targeting for autoimmune diseases. Learn about its potential and ongoing trials. Read why TRML is a hold.

Such cells were thought to be ingested by phagocytes via a pathway that triggers ... that calreticulin-binding receptors, such as C1q and low-density lipoprotein-receptor–related protein ...