例如，虽然 LRRK2 的 G2019S 突变会增强激酶活性，但转基因 G2019S 过表达小鼠和 G2019S 敲入（knock-in，KI）小鼠并不会自发形成典型的 LB 或 LB 样 α-syn 包涵体。同时，体内研究也未能明确证明 G2019S KI 小鼠存在主要的自噬溶酶体途径（autophagy-lysosomal pathway，ALP ...

(Phospho)proteomic analyses of cellular models of LRRK2 and PINK1 should aid the ... cell to remove aggregating protein may involve both autophagy and the UPS. Released aggregated α-synuclein ...

The researchers found, as expected from prior studies that LRRK2 is associated with IBD-PD and discovered new associations as well. Their ability to identify new genes involved in autophagy and ...

Their findings point to mutations in the LRRK2 gene as a common element linking ... inflammation, and autophagy, the body's cellular recycling system, that are involved in both conditions.