为优化晚期透明细胞肾细胞癌（ccRCC）联合治疗，研究人员发现 LRRK2 靶点，开发 LR-protac 增效。 在晚期透明细胞肾细胞癌（ccRCC）的治疗中，酪氨酸激酶抑制剂（TKI）和免疫检查点抑制剂（ICI）联合疗法正逐渐成为重要的治疗策略。为了确定可优化 ccRCC 中 TKI 和 ...

SOUTH SAN FRANCISCO, Calif.--(BUSINESS WIRE)--#LRRK2--Neuron23® Inc., a clinical-stage biotechnology company focused on developing precision medicines for genetically defined neurological and ...

iPD 和 LRRK2 PD 患者 PBMCs 的 mtDNA 缺陷水平显著增加 ... 溶酶体功能障碍和自噬（Lysosomal dysfunction and autophagy） 溶酶体在 PD 发病机制中起着关键作用，负责细胞内废物、受损蛋白质和细胞碎片的降解和回收。PD 的一个标志性病理特征是神经元内异常蛋白质聚集体 ...

Axons of dopaminergic neurons projecting from substantia nigra to striatum are severely affected in the early stage of Parkinson's disease (PD), with axonal degeneration preceding the loss of cell ...

David’s laboratory has studied the roles of autophagy in neurodegeneration ever since his laboratory discovered that this pathway plays an important role in degrading many of the intracytoplasmic, ...