Autophagy is a highly conserved lysosomal degradation system that involves the creation of autophagosomes, which eventually fuse with lysosomes and breakdown misfolded proteins and damaged organelles ...

例如，虽然 LRRK2 的 G2019S 突变会增强激酶活性，但转基因 G2019S 过表达小鼠和 G2019S 敲入（knock-in，KI）小鼠并不会自发形成典型的 LB 或 LB 样 α-syn 包涵体。同时，体内研究也未能明确证明 G2019S KI 小鼠存在主要的自噬溶酶体途径（autophagy-lysosomal pathway，ALP ...

As a crucial cellular process involved in degrading and recycling damaged organelles and proteins, autophagy-related (ATG) proteins mediated autophagy plays a significant role in various physiological ...

SOUTH SAN FRANCISCO, Calif.--(BUSINESS WIRE)--#LRRK2--Neuron23® Inc., a clinical-stage biotechnology company focused on developing precision medicines for genetically defined neurological and ...

Axons of dopaminergic neurons projecting from substantia nigra to striatum are severely affected in the early stage of Parkinson's disease (PD), with axonal degeneration preceding the loss of cell ...

David’s laboratory has studied the roles of autophagy in neurodegeneration ever since his laboratory discovered that this pathway plays an important role in degrading many of the intracytoplasmic, ...