During DNA replication, the unwinding of strands leaves a single strand vulnerable. How does the cell protect these strands from damage? How would you identify the protein that serves as a ...

DNA replication is one of the most basic processes ... whereas the other is called the lagging strand. The leading strand is synthesized continuously, as shown in Figure 5. In contrast, the ...

and another clamp loader called RFC in both human and yeast to thread the clamp onto the lagging strand. The clamp then closes and signals to the polymerases that they can begin replicating DNA.

The helicase was observed to bind the DNA in a cyclic motion, pulling the tracking or leading strand through binding loops while directing the non-tracking or lagging strand out of the complex.