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Leveraging a novel protein tagging strategy offers new route to cancer treatment
In a pioneering collaboration with AbbVie, Northwestern researchers have discovered a new way to potentially treat cancer by targeting and removing harmful proteins from cells. An emerging ...
Nature's warriors: How rice plants detect and defend against viral invaders
A new study has uncovered a molecular mechanism by which rice cells perceive viral infections and initiate antiviral response ...
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RNA ligases and RNA repair
ATP-dependent RNA ligases join 3’-OH and 5’-PO 4 RNA termini via three nucleotidyl transfer steps similar to those of DNA ligases: (Step 1) ligase reacts with ATP to form a covalent ...
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DNA Damage Recognition and Repair by DNA Ligases
The DNA repair and replication pathways converge on a common final step in which the continuity of the repaired DNA strand is restored by DNA ligase, an enzyme that converts nicks into phosphodiester ...
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Developing a simple, cost-effective method to identify the targets of a crucial protein-modifying enzyme
The diversity of cellular functions of ubiquitination is reflected in the existence of over 600 human E3 ligase genes, representing approximately 3% of the human genome. Mapping the human E3 ...