This important study shows that nutrient stress emanating from the microenvironment induces metabolic vulnerabilities in pancreatic ductal adenocarcinoma (PDAC). Using a combination of cell-based and ...

New research suggests that decreased activity of ELOVL2 -- a key enzyme in lipid metabolism -- accelerates white blood cell aging and alters genes associated with the onset of blood cancers.

Lipid metabolism has emerged as a central player in the progression and therapy resistance of breast cancer, particularly the aggressive subtype known as triple-negative breast cancer (TNBC).

Obesity and related metabolic disorders, such as hyperlipidemia and non-alcoholic fatty liver disease, have become ...

Lipid metabolism has emerged as a central player in the progression and therapy resistance of breast cancer, particularly the aggressive subtype ...

Non-alcoholic fatty liver disease (NAFLD) is a hepatic metabolic syndrome resulting from lipid metabolic imbalance.

A metabolic vulnerability of pancreatic ductal adenocarcinoma (PDAC) could be used to address this type of cancer that often resists treatments. Scientists at the University of Michigan have ...

Image Caption: Dysregulation of lipid metabolism promotes EMT (by Figdraw). Down-regulation of ELOVL2 promotes EMT in breast cancer by up-regulating expression of SREBP1/2. Genes & Diseases ...

New research finds reduced ELOVL2 enzyme activity speeds up immune cell aging and disrupts genes linked to cancer.