Cryo-EM analysis of the actinoporin Fav pore reveals octameric structure binding 112 lipids and clusters of cholesterols. Molecular simulations highlight complex protein-lipid interactions crucial ...

Both the pitavastatin molecule and the lactone metabolite undergo very little metabolism by CYP3A4 and, therefore, unlike some other statins, does not interact with CYP3A4 substrates. Pitavastatin ...

This manuscript presents a detailed characterization of male and female wildtype and Ctrp10 knockout mice, and reveals that knockout mice develop female-specific obesity that is largely uncoupled from ...

Research into selective androgen receptor modulators (SARMs) continues to evolve in laboratory settings. Ostarine and ...

Antibiotic-resistant bacteria are a serious public health threat. Understanding the biology of these bacteria—such as how ...

Antibiotic-resistant bacteria is a serious public health threat. Understanding the biology of these bacteria--such as how they synthesise their protective capsules--is essential for developing new ...

TFE3 fusion proteins are the oncogenic drivers of translocation renal cell carcinoma but their mechanism of action remains ...

What we’re discovering is that mitochondrial support is not just about talents energy substrates, it’s also about keeping these vital organelles safe from the onslaught of environmental stressors we ...

Key nutrients like omega-3 fatty acids, curcumin, and NAD+ are important for maintaining cognitive function, but their ...

SINGAPORE: Antibiotic-resistant bacteria pose a significant threat to public health, and researchers from the Yong Loo Lin School of Medicine at the National Un ...