Sunshine Biopharma Inc. has completed additional studies on orthotopic human tumor models in mice confirming its K1.1 mRNA lipid nanoparticle (K1.1-mRNA-LNP) product as a novel therapeutic agent for ...

Lipid nanoparticle (LNP) mRNA vaccines emerged during the COVID-19 pandemic to form an almost miraculous protection against a virus, which killed millions around the world. Aided by expedited ...

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mRNA-LNP 疫苗在新冠防控中发挥重要作用，但存在免疫激活过度等问题。研究人员聚焦 LNP 修饰、miRNA 调控及精准佐剂策略，发现多种方法可优化疫苗，这有望提升疫苗安全性和免疫原性，为疫苗改进提供方向。 在新冠疫情这场没有硝烟的战争中，mRNA 疫苗成为了 ...

提出了一种名为“纤维化过表达与滞留（FORT）”的新策略，通过设计新型脂质纳米颗粒（LNP）和mRNA修饰，显著提高了治疗蛋白在纤维化肝脏中的表达和滞留，为MASH治疗带来了新的希望。 MASH是一种复杂的肝脏疾病，其特征是肝脏脂肪堆积、炎症和纤维化。

showing that Dsc2 mRNA injections temporarily prevented disease progression and restored heart function in Dsc2-deficient mice, and also had promising therapeutic effects in the transverse aortic ...