New antibody-drug conjugate (ADC) candidate, ZW327, exhibits anti-tumor activity and a favorable pharmacokinetics profile in Ly6E-bearing cancers VANCOUVER, British Columbia, March 25, 2025 (GLOBE ...

Utilization of a superior Ly6E binding and internalizing antibody with a proprietary topoisomerase 1 inhibitor payload, ZD06519, lends ZW327 a highly differentiated profile, with pronounced in ...

Different types of antibodies are produced by your immune system. These five antibodies help fight disease by detecting viruses, bacteria, and other pathogens (disease-causing microorganisms) and ...

多发性骨髓瘤（MM）相关骨病（MBD）严重影响患者生活质量且发病机制不明。研究人员整合基因表达综合数据库（GEO）数据集等开展研究，发现 LY6E 促进 MM 细胞增殖和破骨细胞分化，是 MM 预后不良的标志物，为 MM 治疗提供新方向。 在血液肿瘤的领域中 ...

为探究系统性红斑狼疮（SLE）的免疫发病机制，研究人员开展了关于 LY6E 在巨噬细胞中作用的研究。结果发现 LY6E 可调节 IL-1β 产生等，且 IL-1β 与 IFN-α 或 ICs 有协同效应。这为 SLE 治疗提供潜在靶点，具有重要意义。 系统性红斑狼疮（Systemic Lupus Erythematosus ...

Attribution (BY): Credit must be given to the creator. Immunoreagents, most commonly antibodies, are integral components of lateral flow immunoassays. However, the use of antibodies comes with ...

The US Food and Drug Administration announced Thursday that it will be phasing out a requirement that monoclonal antibodies and other drugs be tested on animals, saying in a news release that ...

Importantly, the biomarkers were validated for expression by reverse transcription-quantitative polymerase chain reaction (RT-qPCR). Results: The biomarkers MX1, LY6E, IFI44 and OASL were screened by ...

This includes HSV-1, the type most commonly linked to cold sores, and HSV-2, the type mainly associated with genital herpes. The test doesn't detect the virus itself but instead detects ...