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探寻突触稳态与抑郁症关联,解锁抗抑郁新靶点
研究表明,答案是肯定的。在动物实验中,KCNQ 型 K?通道开放剂可以减少社交挫败应激小鼠的抑郁症样行为;Kir4.1 抑制剂 Lys05 在多种动物模型中展现出快速抗抑郁效果;TREK1 通道的阻断剂也能发挥抗抑郁作用。这些研究结果为开发基于离子通道调节的抗抑郁药物 ...
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