Evidence suggests that in Parkinson’s disease, a breakdown in lysosomal function allows lipids to build up within cells. Variants of the GBA1 gene, the strongest genetic risk factor for sporadic PD, ...

The STING protein, known for helping cells fight viral infections by generating inflammation, also appears to function as a ...

This study reports that activation of TFEB promotes lysosomal exocytosis and clearance of cholesterol from lysosomes, the strength of evidence for which is convincing with appropriate and validated ...

Collaborative Innovation Center of Yangtze River Delta Region Green Pharmaceuticals, College of Pharmaceutical Sciences, Zhejiang University of Technology, China; Department of Molecular, Cellular, ...

Lysosomes are membrane-bound organelles in cells that act as recycling centers—breaking down waste materials, damaged ...

Researchers have long wondered why some people with high-risk Parkinson’s gene variants develop the disease while others ...

But why lysosomal dysfunction causes neuroinflammation ... This "transmembrane" region is known to house a channel that helps membranous vesicles, such as lysosomes, regulate pH—a measure ...