Manuscript Summary Submission Deadline 5 August 2025 | Manuscript Submission Deadline 23 November 2025 ...

Creative Commons (CC): This is a Creative Commons license. Attribution (BY): Credit must be given to the creator. Single extracellular vesicle (EV) research holds the potential to revolutionize our ...

Here, we describe the isolation and structure determination of proteins in membrane vesicles derived directly from cells. Structures of the ion channel Slo1 from total cell membranes and from cell ...

Given the contribution of EC-derived EVs to atherosclerosis, this model represents the first in vivo murine approach to tracking intercellular EC-EV communication within the plaque. It provides an ...

Lysosomal dysfunction may lead to the leakage of toxic substances within brain cells, thus contributing to the onset of Parkinson's disease. Pietro De Camilli, MD, John Klingenstein Professor of ...

2022; Meyer et al., 2014). Since the CCC and Commander complexes are both involved in endosomal recycling, the researchers wondered whether they help ferry lysosomal proteins to their destination.

elegans, ATG-9 vesicles selectively accumulate around ... enhanced the repair of mildly damaged lysosomes and improved lysosomal function, thus rescuing autophagy defects. Further investigation ...

But why lysosomal dysfunction causes neuroinflammation ... This "transmembrane" region is known to house a channel that helps membranous vesicles, such as lysosomes, regulate pH—a measure ...

Department of Biospectroscopy and Bioelectrochemistry, Institute of Biochemistry, Life Sciences Center, Vilnius University, Saulėtekio av. 7, Vilnius LT-10257, Lithuania ...