Lysosome-related organelles (LROs) or granules are the main protease storage and processing organelles of the endolysosomal system. The range of proteases present in LROs is cell-type specific.

De Duve named these new organelles "lysosomes" to reflect their lytic nature. That same year, Alex Novikoff from the University of Vermont visited de Duve´s laboratory. An experienced ...

This bubble then merges with the lysosome, where the contents are broken ... leading to the buildup of waste inside cells and human diseases. "We're excited about the potential of this research ...

Furthermore, they found that downregulation of BAG3, a protein involved in protein clearance through the autophagy-lysosome pathway ... in the mouse models and human post-mortem brain tissue ...