BACKGROUND: Heart failure with preserved ejection fraction (HFpEF) has become the most prevalent type of heart failure, but ...

Strengths: The implications for health, disease, and therapeutic discovery are considerable, given the central role of autophagy and lysosome-related pathways in regulating critical cellular processes ...

Internalized 19CAR(1a) co-localizes more with early and recycling endosomes, and less with lysosomes than 19CAR(8α). These features result in lower activation levels, less cytokine release, and ...

Division of Multi-Organ Transplantation, Department of Surgery, University of California, San Francisco, United States; Bakar Computational Health Sciences Institute, University of California, San ...

National Engineering Research Center of Ophthalmology and Optometry, School of Biomedical Engineering, Eye Hospital, Wenzhou Medical University, Wenzhou 325027, China ...

Background: Neuraminidase-1 (NEU1) is an enzyme that breaks down sialic acids on glycoproteins and glycolipids. Aberrant expression of NEU1 has been linked to the progression of numerous malignancies, ...

Three local genetic correlation (LGC) genomic prediction methods are proposed to incorporate LGCs into multi-trait genomic prediction and could universally improve prediction accuracy compared to ...

Additionally, the cellular recycling plants—called lysosomes—were missing key digestive enzymes responsible for breaking down waste products, the scientists found. "These vesicles can't reach ...

School of Chemistry and Chemical Engineering, Hunan Key Laboratory for the Design and Application of Actinide Complexes, University of South China, 28 Changsheng West Road, Hengyang, Hunan 421001, P.

Nes, BM ∙ Janszky, I ∙ Aspenes, ST ∙ et al.

PIKfyve is an enzyme thought to be involved in an underlying disease process in ALS linked to the function of lysosomes ... and develop patient response markers and hitherto unaddressed drug ...