Damaged lysosomes are repaired by a lipid-based signaling pathway dubbed PITT that could be targeted to treat neurodegenerative disease, its discoverers say. Holly Barker is a freelance journalist ...

This project is to determine TFEB PTM signatures induced by tau that drive TFEB nuclear signaling. The hypothesis is that intraneuronal Tau accumulation acts as a lysosomal stress signal to activate ...

Kanazawa University, report in Nature Communications how the targeted suppression of lysosome function may lead to brain cancer therapy.

Zhou, Q.H., Li, H.M., and Xue, D. (2011). Elimination of Paternal mitochondria through the lysosomal degradation pathway in C. elegans. Cell Research 21, 1662-1669 ...

(3) A portion of mitochondria budding off as mitochondria-derived vesicles and fuse with lysosomes for degradation. (4) Depolarised mitochondria undergo morphological remodelling to squeeze their ...

We wanted to determine what happens to the cell when the lysosomes are not functioning well or are overwhelmed, and if there was another pathway to temporarily deal with the damaged mitochondria. This ...

Fats and other cellular materials reach the lysosome through three main pathways: endocytosis, phagocytosis, and autophagy. In endocytosis, the cell takes in materials from outside by wrapping ...

The Overholtzer lab studies mechanisms of nutrient sensing and cellular responses to nutrient starvation, including the nutrient recycling pathway autophagy, scavenging pathways such as ... The lab ...

It has a range of preclinical-stage projects that aim to harness lysosomes’ ability to clear toxic materials and defective cellular components. Mutations that impair cellular clearance pathways ...